SciCombinator

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This study aims to promote reflection and bring attention to the potential adverse effects of academic social networks on science. These academic social networks, where authors can display their publications, have become new scientific communication channels, accelerating the dissemination of research results, facilitating data sharing, and strongly promoting scientific collaboration, all at no cost to the user.One of the features that make them extremely attractive to researchers is the possibility to browse through a wide variety of bibliometric indicators. Going beyond publication and citation counts, they also measure usage, participation in the platform, social connectivity, and scientific, academic and professional impact. Using these indicators they effectively create a digital image of researchers and their reputations.However, although academic social platforms are useful applications that can help improve scientific communication, they also hide a less positive side: they are highly addictive tools that might be abused. By gamifying scientific impact using techniques originally developed for videogames, these platforms may get users hooked on them, like addicted academics, transforming what should only be a means into an end in itself.

Concepts: Scientific method, Sociology, Academic publishing, Science, Research, Academia, Addiction, Adverse drug reaction

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The objective of this study was to investigate the effects of poly (amido amine) (PAMAM), composite with nanoparticles of amorphous calcium phosphate (NACP), and the combined PAMAM+NACP nanocomposite treatment, on remineralization of demineralized dentin in a cyclic artificial saliva/lactic acid environment for the first time.

Concepts: DNA, Bone, Amino acid, Amine, Ammonia, Calcium, Carbonyl, Aniline

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Extracorporeal membrane oxygenation (ECMO) for cardiopulmonary support of critically ill patients is used frequently in the pediatric population. ECMO is burdened by complications, including thrombosis and hemorrhage. Here we demonstrate the focused location of clots, their histological composition, and the relationship of in situ thrombus to local hemodynamics in ECMO circuits.Pediatric ECMO circuits from Children’s Healthcare of Atlanta, Emory University (Atlanta, GA) were obtained following removal from extracorporeal support over a 2.5-year period (n=50). All clots and material deposited within the circuit were recorded. Location of clot was compared with local hemodynamics.Most clots were adherent to the junctions made by the tubing and connectors, as opposed to being randomly disturbed throughout the circuit tubing (p<0.05). Loose, non-adherent clots were also found at the entry side of oxygenators. The clots co-located directly with zones of low shear rate. Histology revealed a fibrinous composition, consistent with coagulation potentiated by low shear.Centrifugal pump circuits (n=16) had more clots than roller pump (n=34) circuits (p<0.05). In addition, all centrifugal pumps had clots that formed at the top of the pump shaft.The ECMO circuits from our single-center study demonstrate the concentrated location of fibrin clots at low shear zones created by tubing connector junctions (TCJs). Type of pump also influences the frequency of clot formation. Since the mechanism of the majority of ECMO circuit thrombosis is low-shear and fibrin driven, optimization of hemodynamics and anticoagulation regimen may reduce clot formation and bleeding.

Concepts: Blood, Coagulation, Fibrin, Warfarin, Hemostasis, Thrombus, Extracorporeal membrane oxygenation, The Circuit

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Botulinum toxin type A (BTA) has been approved for the treatment of strabismus, blepharospasm, muscle spasm, cervical dystonia, pain syndrome, glabella wrinkles, and severe primary axillary hyperhidrosis. Intradermal injection of BTA has been used off-label by many clinicians for the purpose of face-lifting effect. Few studies on onabotulinumtoxinA (ONA) demonstrated no clinical efficacy on face-lifting effect when comparing to normal saline solution (NSS). So far, there is no split-face comparison study on face-lifting effect of abobotulinumtoxinA (ABO).

Concepts: Pharmacology, Clinical trial, Randomized controlled trial, Effectiveness, Dystonia, Botulinum toxin, Hyperhidrosis, Blepharospasm

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To investigate the effects of LCL161, a Smac mimetic, on the proliferation and apoptosis in hepatocellular carcinoma cells and the underlying mechanisms. 


Concepts: Cancer, Squamous cell carcinoma

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To investigate the expression of miR-33b in hepatocellular carcinoma (HCC) and to explore regulatory mechanism of miR-33b for cell proliferation of HCC.


Concepts: Cancer, Bacteria, The Expression of the Emotions in Man and Animals

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To determine the combined cytotoxic effect and the molecular basis of triptolide and sodium cantharidinate on hepatoma cell line 7721.


Concepts: DNA, Cell, Ion