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Journal: The spine journal : official journal of the North American Spine Society


Wound dehiscence and SSI’s can have a profound impact on patients, as they often require hospital re-admission, additional surgical interventions, lengthy IV antibiotic administration and delayed rehabilitation. Negative pressure wound therapy(NPWT) exposes the wound site to negative pressure, resulting in the improvement of blood supply, removal of excess fluid and stimulation of cellular proliferation of granulation tissue.

Concepts: Immune system, Blood, Wound healing, Hospital, Infection, Chronic wound, Negative pressure wound therapy, Wound dehiscence


Hypoalbuminemia is associated with increased morbidity and mortality in various clinical settings and several major diseases. Albumin has multiple physiologic properties that could be beneficial in central nervous system injury.

Concepts: Central nervous system, Nervous system, Spinal cord, Brain, Paralysis


Information on short- and especially long-term mortality among patients with infectious spondylodiscitis is sparse.

Concepts: Hedge fund


Studies have shown that pain acceptance strategies related to psychological flexibility are important in the presence of chronic musculoskeletal pain. However, the predictors of these strategies have not been studied extensively in patients with Whiplash Associated Disorders (WAD).

Concepts: Cultural studies, Whiplash


Heterogeneity exists within the low back pain population. Some patients recover after every pain episode, whereas others suffer daily from LBP complaints. Until now, studies rarely make a distinction between recurrent low back pain (RLBP) and chronic low back pain (CLBP), although both are characterized by a different clinical picture. Clinical experiences also indicate that heterogeneity exists within the CLBP population. Muscle degeneration, like atrophy, fat infiltration, alterations in muscle fiber type and altered muscle activity, compromises proper biomechanics and motion of the spinal units in low back pain (LBP) patients. The amount of alterations in muscle structure and muscle function of the paraspinal muscles, might be related to the recurrence or chronicity of LBP.

Concepts: Spinal disc herniation, Low back pain, Back pain, Muscle, Pain, Electromyography, Acupuncture, Massage


Patients with large annular defects following lumbar diskectomy for disk herniation are at high risk for symptomatic recurrence and reoperation.


The role of arthrodesis in the surgical management of lumbar spondylolisthesis remains controversial. We hypothesized that practice patterns and outcomes for this patient population may vary widely.


Disc degeneration (DD) is a significant driver of low back pain and few treatments exist to treat the pain and disability associated with the disease.


The correlation between physical inactivity, thoracolumbar disc degeneration, and back pain remains unclear PURPOSE: This study investigated the relationship between short- and long-term physical inactivity and degenerative changes of the thoracic and lumbar spine in a southern German cohort from the general population over a time period of 14 years.


Vertebral fragility fractures (VFF), mostly due to osteoporosis, are very common and are associated with significant morbidity and mortality. There is a lack of consensus on the appropriate management of patients with or suspected of having a VFF.