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Journal: Journal of surgical oncology


Signet ring cell carcinoma (SRC) of the stomach is known to have different microscopic and biologic characteristics compared to non-SRC. The pathologic report has documented partly SRC component with main histologies. However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC).

Concepts: Cancer, Metastasis, Histology, Stomach, Squamous cell carcinoma, Helicobacter pylori, Stomach cancer, Signet ring cell carcinoma


Both enchondroma and atypical cartilaginous tumors (ACT) are not considered malignant, so inactive and asymptomatic tumors might not need surgery. To the best of our knowledge, this is the first study that has been done to evaluate the natural course of conservative-treated enchondroma and ACT in the long bones.

Concepts: Bone, Cancer, Oncology, Medical terms, Greatest hits albums, Greatest hits, Radiohead


Pancreaticobiliary maljunction (PBM) may be associated with an increased frequency of gall bladder cancer with no bile duct dilation. Karyopherin-α2 (KPNA2) and stathmin 1 (STMN1) were reported to play important roles in carcinogenesis and cancer progression.

Concepts: Digestive system, Epithelium, Liver, Hepatology, Bile, Bile duct, Gallbladder, Cholecystokinin



To assess the risk factors of positive surgical margins (PSM) and the influence of margin status on recurrence in pT1 clear cell renal cell carcinoma (RCC) following partial nephrectomy (PN).

Concepts: Kidney, Squamous cell carcinoma, Renal cell carcinoma, Nephrectomy, Surgical oncology


An estimated 200,000 deaths each year worldwide are due to cancer of the head and neck, mostly mucosal squamous cell carcinoma and nonmelanoma skin cancer. The status of surgical margins is important for prognosis and need for adjuvant therapy. We will discuss how margin status impacts outcomes and therapy, and the conundrum of determining margin status. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc.

Concepts: Cancer, Lung cancer, Types of cancer, Carcinoma, Squamous cell carcinoma, Squamous epithelium, Head and neck cancer, Skin cancer


The objective of the current study was to define long-term survival of patients with resectable hilar cholangiocarcinoma (HCCA) after preoperative percutaneous transhepatic biliary drainage (PTBD) versus endoscopic biliary drainage (EBD).

Concepts: Hepatology, Adverse drug reaction, The Current, Bile duct, Cholangiocarcinoma, Klatskin tumor, Endoscopic retrograde cholangiopancreatography


Anastomotic stricture following esophagogastrectomy (EG) can lead to significant dysphagia, necessitating interventions such as endoscopic dilatation. These post-operative complications gain importance with the increased survival rate of patients after EG. This study aimed to assess the outcomes of both circular-stapled (CS: 25 and 29 mm) and hand-sewn (HS) anastomoses after EG.

Concepts: Obesity, Esophageal varices, Squamous cell carcinoma, Helicobacter pylori, Gastroesophageal reflux disease, Anastomosis, Achalasia, Nitrosamine


The objective of this study was to evaluate a revised nodal category based on the value of the lymph node (LN) station ratio (SR, metastatic LN stations/examined LN stations) in esophageal squamous cell carcinoma (ESCC) patients.

Concepts: Cancer, Lung cancer, Lymph node, Squamous cell carcinoma, Squamous epithelium, Barrett's esophagus, Stations of the Cross, Station


We hypothesized that the Oncotype Dx(®) 21-gene Recurrence Score (RS) could guide neoadjuvant systemic therapy (NST) to facilitate breast conserving surgery (BCS) for hormone receptor positive (HR+) breast cancers.

Concepts: Immune system, Cancer, Breast cancer, Metastasis, Biopsy, Chemotherapy, Pleural effusion