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Journal: Cutaneous and ocular toxicology


During the last half of the 20th century, the use of UVB therapy and photochemotherapy (PUVA), were one of the mainstays of treatment for psoriasis. However, accompanying to the advent of the most recent era of psoriasis, with targeted biologic therapy has been a decline in the frequency of phototherapy. This does not diminish its known clinical effects.

Concepts: Medicine, Ultraviolet, Therapy, Sunlight, 20th century, Psoriasis, 21st century, Light therapy


We report an unusual case of bilateral eyelid erythema caused by eyelash glue. A 22-year-old woman presented with a 3-day history of bilateral eyelid dermatitis after attaching false eyelashes by using latex-containing glue. Slit-lamp examination revealed erythema and swelling of the upper lids of both eyes. The skin prick test was positive for eyelash glue and her total tear IgE score was high. To the best of our knowledge, this is the first report of bilateral eyelid dermatitis caused by eyelash glue.

Concepts: Allergy, Eye, Skin, Greatest hits, Skin allergy test, Eyelid, Eyelash


Cutaneous Adverse Drug Reactions (CADRs) are observed in 2-3% of hospitalized patients. The clinical presentation of the CADRs varies among different populations.

Concepts: Pharmacology, Hospital, Illness, Adverse drug reaction


Abstract Purpose: To evaluate the early retinal changes and its reflection on the visual field examination in chronic hepatitis B (CHB) patients using pegylated interferon-α (PEGIFN-α) monotherapy. Patients and methods: Thirty eyes of fifteen patients with CHB were examined prospectively for changes in the fundus examination and visual field examination (both Humphrey Perimetry and Frequency Doubling Perimetry). The patients were examined before and in 3 months intervals after starting the PEGIFN-α treatment. The changes in the fundus examination were noted and the visual field examinations, retinal nerve fiber thickness, Schirmer scores and color vision before and at 3 months of the treatment were compared. The statistical evaluation was performed with paired-t test, using SPSS 16.0 Inc. (Chicago, IL). Results: The mean age of the 15 patients (seven male, eight female) was 52.5 ± 12.4 years. There was no significant retinal change in none of the patients. Neither the visual field examination with Humphrey Field Analyzer nor the Frequency Doubling Perimetry results has demonstrated any significant change during 3 months follow-up. There was a statistically significant increase in the retinal nerve fiber layer (RNFL) thickness; while Schirmer test scores for dry eye assessment was significantly decreased. Conclusion: PEGIFN-α monotherapy, which is used for treatment of CHB, may cause some changes in the thickness of RNFL that may necessitate the close follow-up for further morphological changes of the optic disc in these patients.

Concepts: Statistics, Hepatitis, Retina, Eye, Hepatitis B, Ophthalmology, Optic nerve, Nerve fiber layer


Abstract Objective: This study compared three model decontaminant solutions (distilled water, 10% distilled water and soap and methanol) for their ability to remove salicylic acid and aminophylline from an in vitro skin model. Materials and methods: Human abdominal skin was dosed with 20 µL of either [(14)C]-aminophylline or [(14)C]-salicylic acid on 1 cm(2) per skin. After each exposure time (5, 30 and 60 min post-dosing, respectively), surface skin was washed three times with each solution and tape stripped 10 times. Wash solutions, tape strips, receptor fluid and remaining skin were then analyzed with liquid scintillation counting to quantify the amount of salicylic acid and aminophylline. Results: Total mass balance recovery for each chemical at three time exposure points was between 73.6 and 101.5%, except at 60 min where aminophylline was only 42.5%. Majority of salicylic acid and aminophylline were recovered from washing solution when compared to stratum corneum, epidermis, dermis, surrounding skin and receptor fluid. Conclusion: The three tested decontaminates possessed similar effectiveness in removing lipophilic and hydrophilic chemicals from the skin. Due to diminishing decontamination efficacy with time, it is suggested that skin should be washed as soon as possible following contamination to minimize percutaneous penetration and the deleterious effects associated with skin reservoir content.

Concepts: Chemistry, Skin, Liquid, Epidermis, Shutter speed, Scintillation counter, Washing, WASH


Since we had observed electroretinographic (ERG) abnormalities in some patients undergoing photochemotherapy with normal eye examination, we decided to investigate the effects of this therapy on retinal function.

Concepts: Effect, Effectiveness, Affect, Retina, Eye, Effects unit


To evaluate the effects of topical everolimus and sunitinib on corneal neovascularization (CNV).

Concepts: Eye, Contact lens, Corneal neovascularization


Abstract Context: Mercury is one of the skin-lightening ingredients in cosmetics as mercury ions are thought to inhibit the synthesis of the skin pigment melanin in melanocyte cells. Objective: The objective of this study was to evaluate the mercury levels of cosmetics currently marketed in Shijiazhuang, a northern city in China. Methods: We collected 146 random cosmetic samples and analyzed for mercury concentrations or levels by cold vapor atomic absorption spectrometry. Results: Among the 146 samples, 134 (91.8%) were positive for mercury, and the concentrations of mercury ranged from not detectable to 592 ng/g. Cosmetic samples for children and babies had the highest detection rate (100%), followed by shampoo and hair conditioner (92.3%) and skin-lightening cream (92.0%). All of them were lower than the acceptable limit (1 μg/g) in China. Discussion and conclusions: Cosmetics for skin had the highest mean mercury content (45 ng/g), followed by hair products (42.1 ng/g). The concentrations of mercury detected in samples were lower than the current legal limit in China, indicating it may not pose a risk to consumers.

Concepts: Spectroscopy, Analytical chemistry, Melanin, Cosmetics, Pigment, Human skin color, Sun tanning, Hair conditioner


Pigmented purpuric dermatoses (PPDs) are a group of histologically similar skin eruptions characterized by a perivascular lymphocytic infiltrate with extravasated erythrocytes. The etiologies of these conditions are unknown, but triggering factors such as systemic diseases, infections, drugs, and foods have been described. Here, we present a patient who developed pigmented purpura 30 days after initiating a dietary supplement that contained selenium, natural vitamin E, and a parsley concentrate, specifically, Parselenium E. One month after stopping the dietary supplement, the lesions disappeared and no new lesions have developed.

Concepts: Immune system, Nutrition, Vitamin, Essential nutrient, Dietary supplement, Dietary mineral, Sepsis, Vitamin E


To investigate the effect of microRNA-16 on hypoxia-induced VEGF expression of ARPE-19 cells Methods: ARPE-19 cells were cultivated under normoxia and hypoxia state. At 0h, 12h, 24h and 48h after cultivation, the supernate of the culture medium were separated to test the VEGF secretion by ELISA, and the cells were purified to measure the expression of VEGF mRNA and microRNA-16 by qRT-PCR; microRNA-16 mimic was then transfected into ARPE-19 cells by the Hiperfect transfection reagent, a liposome transfection system. Scramble group and the non-transfected group were set as the controls. VEGF secretion and the level of VEGF mRNA were measured in these three groups.

Concepts: Angiogenesis, Vascular endothelial growth factor, Psychometrics, Transfection