Discover the most talked about and latest scientific content & concepts.

Journal: American journal of surgery


Our purpose was to determine the relationship between preoperative frailty and the occurrence of postoperative complications after colorectal and cardiac operations.

Concepts: Medicine, Medical specialty


The efficacy of antibiotics in appendicitis remains controversial, and physicians are not confident in prescribing antibiotics as the first line treatment. This network meta-analysis was conducted to assess the efficacy and safety of individual antibiotics in uncomplicated appendicitis.


Optimal surgery for pleomorphic adenoma of the parotid is controversial. In the present review, we discuss the advantages and disadvantages of the various approaches after addressing the surgical pathology of the parotid pleomorphic adenoma capsule and its influence on surgery.

Concepts: Anatomical pathology, Pleomorphic adenoma


Appendicitis is the most common emergency surgical condition of the abdomen in children. This study sought to delineate the presentation and the outcome of appendicitis in children younger than 5 years old.

Concepts: Simeon the Righteous


This study was performed to identify clinicopathologic factors associated with survival in acral lentiginous melanoma.

Concepts: Types of cancer, Melanoma, Lentigo maligna melanoma, Lentigo maligna, Melanocytic nevi and neoplasms, Acral lentiginous melanoma, Lentigo, Bob Marley


In patients with cutaneous melanoma, mitotic rate (MR) historically has been reported as the number of mitoses per high-power field (hpf) or per 10 hpf. The most recent revision of the American Joint Committee on Cancer melanoma staging system now incorporates MR and specifies that MR should be reported as mitoses per mm(2), with a conversion factor of 1 mm(2) equaling 4 hpf. However, because many pathologists continue to report MR in hpf units, we sought to compare the 2 conventions for reporting MR; this is important now that MR is used for staging and prognostic information.

Concepts: Cancer, Lung cancer, Cell cycle, Report, Melanoma, Mitosis, The Colbert Report, Conversion of units


To prevent hepatic failure after major hepatectomy, it is important to assess preoperative factors related to liver failure.

Concepts: Coagulation, Liver, Hepatic encephalopathy, Liver failure


Currently, >200 meshes are commercially available in the United States. To help guide appropriate mesh selection, the investigators examined the postsurgical experiences of all patients undergoing ventral hernia repair at their facility from 2008 to 2011 with ≥12 months of follow-up.

Concepts: United States, Poverty in the United States, U.S. state, Hernia, Concepts in metaphysics, Choice, Mesh, Live Mesh


Intraoperative frozen section analysis is often performed in the surgical management of pancreatic lesions. This test is used to obtain histologic diagnosis, to assess resectability because of unanticipated locoregional spread, and to ensure negative margins after resection. We sought to define the accuracy and clinical usefulness of intraoperative frozen section analysis in patients with pancreatic lesions and to determine the impact on long-term outcomes.

Concepts: Medicine, Medical terms, Anatomical pathology, Histology, Physician, Psychometrics, Frozen section procedure, Microtome


BACKGROUND: We investigated whether single nucleotide polymorphisms (SNPs) of integrin beta 1 (ITGB1) and integrin beta 2 (ITGB2) contribute to the development of papillary thyroid cancer (PTC). METHODS: Two synonymous SNPs (rs2230396 and rs2298141) of ITGB1 and 1 synonymous SNP (rs2352326), 1 5' URT-region SNP (rs2070947), and 1 promoter SNP (rs2070946) of ITGB2 SNPs were genotyped using direct sequencing in 94 patients with PTC and 213 healthy controls. Genetic data were analyzed using SNPStats (, Helix Tree (Golden Helix Inc, Bozeman, MT), and SNPAnalyzer (ISTECH Corp, Goyang City, Republic of Korea). RESULTS: The promoter SNP (rs2070946) of ITGB2 was significantly associated with the development of PTC (dominant model, log-additive model). The G allele frequencies of the promoter SNP (rs2070946) of ITBG2 in patients with PTC (19.9%) were increased by about 2-fold compared with controls (10.2%). CONCLUSIONS: Our results suggest that a promoter SNP (rs2070946) of ITGB2 might be associated with a risk of PTC.

Concepts: DNA, Gene, Genetics, Bioinformatics, Single-nucleotide polymorphism, Genetic genealogy, Population genetics, Integrin