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Concept: Remote control


Google Glass is a recently designed wearable device capable of displaying information in a smartphone-like hands-free format by wireless communication. The Glass also provides convenient control over remote devices, primarily enabled by voice recognition commands. These unique features of the Google Glass make it useful for medical and biomedical applications where hands-free experiences are strongly preferred. Here, we report for the first time, an integral set of hardware, firmware, software, and Glassware that enabled wireless transmission of sensor data onto the Google Glass for on-demand data visualization and real-time analysis. Additionally, the platform allowed the user to control outputs entered through the Glass, therefore achieving bi-directional Glass-device interfacing. Using this versatile platform, we demonstrated its capability in monitoring physical and physiological parameters such as temperature, pH, and morphology of liver- and heart-on-chips. Furthermore, we showed the capability to remotely introduce pharmaceutical compounds into a microfluidic human primary liver bioreactor at desired time points while monitoring their effects through the Glass. We believe that such an innovative platform, along with its concept, has set up a premise in wearable monitoring and controlling technology for a wide variety of applications in biomedicine.

Concepts: Device, Control, Bluetooth, Remote control, Wireless, Keyboard, Wireless energy transfer


PURPOSE The purpose of this study was to compare the benefits of three types of remote microphone hearing assistance technology (HAT), Adaptive Digital broadband, Adaptive Frequency Modulation (FM), and Fixed FM, through objective and subjective measures of speech recognition in clinical and real-world settings. METHODS Participants included 11 adults, ages 16 to 78 years, with primarily moderate-to-severe bilateral hearing impairment (HI) who wore binaural behind-the-ear hearing aids and 15 adults, ages 18 to 30 years, with normal hearing (NH). Sentence recognition in quiet and in noise and subjective ratings were obtained in three conditions of wireless signal processing. RESULTS Performance by the listeners with HI when using the Adaptive Digital technology was significantly better than that obtained with the FM technology, with the greatest benefits at the highest noise levels. The majority of listeners also preferred the digital technology when listening in a real-world noisy environment. The wireless technology allowed persons with HI to surpass persons with NH in speech recognition in noise with the greatest benefit occurring with Adaptive Digital technology. CONCLUSIONS The use of Adaptive Digital technology combined with speechreading cues would allow persons with HI to engage in communication in environments that would have otherwise not been possible with traditional wireless technology.

Concepts: Sound, Audiogram, Radio, Remote control, Wireless, Analog signal, Amateur radio, History of radio


Images of comet 67P/Churyumov-Gerasimenko acquired by the OSIRIS (Optical, Spectroscopic and Infrared Remote Imaging System) imaging system onboard the European Space Agency’s Rosetta spacecraft at scales of better than 0.8 meter per pixel show a wide variety of different structures and textures. The data show the importance of airfall, surface dust transport, mass wasting, and insolation weathering for cometary surface evolution, and they offer some support for subsurface fluidization models and mass loss through the ejection of large chunks of material.

Concepts: Jupiter, Space exploration, Remote control, Comet, Solar and Heliospheric Observatory, European Space Agency, Stardust, Ariane 5


The development of lightweight, superportable, and sustainable power sources has become an urgent need for most modern personal electronics. Here, we report a cut-paper-based self-charging power unit (PC-SCPU) that is capable of simultaneously harvesting and storing energy from body movement by combining a paper-based triboelectric nanogenerator (TENG) and a supercapacitor (SC), respectively. Utilizing the paper as the substrate with an assembled cut-paper architecture, an ultralight rhombic-shaped TENG is achieved with highly specific mass/volume charge output (82 nC g(-1)/75 nC cm(-3)) compared with the traditional acrylic-based TENG (5.7 nC g(-1)/5.8 nC cm(-3)), which can effectively charge the SC (∼1 mF) to ∼1 V in minutes. This wallet-contained PC-SCPU is then demonstrated as a sustainable power source for driving wearable and portable electronic devices such as a wireless remote control, electric watch, or temperature sensor. This study presents a potential paper-based portable SCPU for practical and medical applications.

Concepts: Electricity, Engineering, Trigraph, Computer, Electronics, Electronic engineering, Remote control, Watch


The Reveal LINQ™ is a miniaturized insertable cardiac monitor (ICM) with wireless telemetry for remote monitoring patients with suspected arrhythmias.

Concepts: Monitoring, Cardiac arrest, Cardiac electrophysiology, Remote control, Wireless


Upconversion nanocrystals convert infrared radiation to visible luminescence, and are promising for applications in biodetection, bioimaging, solar cells and three-dimensional display technologies. Although the design of suitable nanocrystals has improved the performance of upconversion nanocrystals, their emission brightness is limited by the low doping concentration of activator ions needed to avoid the luminescence quenching that occurs at high concentrations. Here, we demonstrate that high excitation irradiance can alleviate concentration quenching in upconversion luminescence when combined with higher activator concentration, which can be increased from 0.5 mol% to 8 mol% Tm(3+) in NaYF4. This leads to significantly enhanced luminescence signals, by up to a factor of 70. By using such bright nanocrystals, we demonstrate remote tracking of a single nanocrystal with a microstructured optical-fibre dip sensor. This represents a sensitivity improvement of three orders of magnitude over benchmark nanocrystals such as quantum dots.

Concepts: Chemistry, Quantum dot, Electromagnetic spectrum, Solar cell, Light-emitting diode, Infrared, Nanocrystal, Remote control


April 25, 2015, began like any other day at the remote Himalayan Rescue Association (HRA) clinic in Pheriche, Nepal, where I’d been working as a volunteer physician for the past 6 weeks. Days had passed quickly while our team cared for international trekkers and climbers, as well as local Nepalis, treating routine illnesses and addressing high-altitude emergencies. But on this day around noon, the ground began quaking beneath my feet as I sat in our living space. My bewilderment quickly dissipated as I darted outdoors to join the rest of the village in the open spaces. Time seemed to slow . . .

Concepts: Time, Medicine, Space, Nepal, Remote control, Apostrophe


The capability to detect traces of explosives sensitively, selectively and rapidly could be of great benefit for applications relating to civilian national security and military needs. Here, we show that, when chemically modified in a multiplexed mode, nanoelectrical devices arrays enable the supersensitive discriminative detection of explosive species. The fingerprinting of explosives is achieved by pattern recognizing the inherent kinetics, and thermodynamics, of interaction between the chemically modified nanosensors array and the molecular analytes under test. This platform allows for the rapid detection of explosives, from air collected samples, down to the parts-per-quadrillion concentration range, and represents the first nanotechnology-inspired demonstration on the selective supersensitive detection of explosives, including the nitro- and peroxide-derivatives, on a single electronic platform. Furthermore, the ultrahigh sensitivity displayed by our platform may allow the remote detection of various explosives, a task unachieved by existing detection technologies.

Concepts: Molecular biology, Chemistry, Nitrogen, Array, Explosive material, Remote control, Nitroglycerin, Dynamite


BACKGROUND: /st>Although telemedicine is one of the key initiatives of the World Health Organization, no study has explored the feasibility and efficacy of teleanaesthesia. This bi-centre pilot study investigates the feasibility of transcontinental anaesthesia. METHODS: /st>Twenty patients aged ≥18 yr undergoing elective thyroid surgery for ≥30 min were enrolled in this study. The remote and local set-up was composed of a master-computer (Montreal) and a slave-computer (Pisa). Standard Internet connection, remote desktop control, and video conference software were used. All patients received total i.v. anaesthesia controlled remotely (Montreal). The main outcomes were feasibility, clinical performance, and controller performance of transcontinental anaesthesia. The clinical performance of hypnosis control was the efficacy to maintain bispectral index (BIS) at 45: ‘excellent’, ‘good’, ‘poor’, and ‘inadequate’ control represented BIS values within 10, from 11 to 20, from 21 to 30, or >30% from target. The clinical performance of analgesia was the efficacy to maintain Analgoscore values at 0 (-9 to 9); -3 to +3 representing ‘excellent’ pain control, -3 to -6 and +3 to +6 representing ‘good’ pain control, and -6 to -9 and +6 to +9 representing ‘insufficient’ pain control. The controller performance was evaluated using Varvel parameters. RESULTS: /st>Transcontinental anaesthesia was successful in all 20 consecutive patients. The clinical performance of hypnosis showed an ‘excellent and good’ control for 69% of maintenance time, and the controller performance showed an average global performance index of 57. The clinical performance of analgesia was ‘excellent and good’ for 92% of maintenance time, and the controller performance showed a global performance index of 1118. CONCLUSIONS: /st>Transcontinental anaesthesia is feasible; control of anaesthesia shows good performance indexes.Clinical registration numberNCT01331096.

Concepts: Anesthesia, Opioid, Pain, Control theory, World Health Organization, Index Librorum Prohibitorum, Remote control, Remote desktop


Protein catalysis requires the atomic-level orchestration of side chains, substrates and cofactors, and yet the ability to design a small-molecule-binding protein entirely from first principles with a precisely predetermined structure has not been demonstrated. Here we report the design of a novel protein, PS1, that binds a highly electron-deficient non-natural porphyrin at temperatures up to 100 °C. The high-resolution structure of holo-PS1 is in sub-Å agreement with the design. The structure of apo-PS1 retains the remote core packing of the holoprotein, with a flexible binding region that is predisposed to ligand binding with the desired geometry. Our results illustrate the unification of core packing and binding-site definition as a central principle of ligand-binding protein design.

Concepts: Metabolism, Enzyme, Protein structure prediction, Ligand, Lone pair, Principle, Remote control, Protein design