SciCombinator

Discover the most talked about and latest scientific content & concepts.

Concept: Radical mastectomy

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Rates of contralateral prophylactic mastectomy (CPM) have markedly increased but we know little about the influence of surgeons on variability of the procedure in the community.

Concepts: Cancer, Breast cancer, Metastasis, Estrogen, Pleural effusion, Breast, Mastectomy, Radical mastectomy

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Prophylactic skin-sparing mastectomy (SSM) is associated with major breast cancer risk reduction in high-risk patients. In prophylactic nipple-sparing mastectomy (NSM) it is unknown how many terminal duct lobular units (TDLUs) remain behind the nipple-areola complex (NAC) additionally to those behind the skin flap. Therefore, safety of NSM can be doubted. We compared amounts of TDLUs behind the NAC as compared with the skin. In prophylactic SSM and conventional therapeutic mastectomy patients, the NAC and an adjacent skin island (SI) were resected as if it were an NSM. NAC and SI were serially sectioned perpendicularly to the skin and analyzed for the amount of TDLUs present. Slides of NAC and SI were scanned, and slide surface areas (cm) were measured. TDLUs/cm in NAC versus SI specimen, representing TDLU density, were analyzed pairwise. In total, 105 NACs and SIs of 90 women were analyzed. Sixty-four NACs (61%) versus 25 SIs (24%) contained ≥1 TDLUs. Median TDLU density was higher in NAC specimens (0.2 TDLUs/cm) as compared with SI specimens (0.0 TDLUs/cm; P<0.01). Independent risk factors for the presence of TDLUs in the NAC specimen were younger age and parity (vs. nulliparity). The finding of higher TDLU density behind the NAC as compared with the skin flap suggests that sparing the NAC in prophylactic NSM in high-risk patients possibly may increase postoperative breast cancer risk as compared with prophylactic SSM. Studies with long-term follow-up after NSM are warranted to estimate the level of residual risk.

Concepts: Cancer, Breast cancer, Metastasis, Carcinoma in situ, Breast, Units of measurement, Specimen, Radical mastectomy

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Surgery after initial lumpectomy to obtain more widely clear margins is common and may lead to mastectomy.

Concepts: Cancer, Breast cancer, Metastasis, Chemotherapy, Breast, Surgical oncology, Mastectomy, Radical mastectomy

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Accredited breast centers in the United States are measured on performance of breast conservation surgery (BCS) in the majority of women with early-stage breast cancer. Prior research in regional and limited national cohorts suggests a recent shift toward increasing performance of mastectomy in patients eligible for BCS.

Concepts: Cancer, Breast cancer, Metastasis, United States, Estrogen, Chemotherapy, Breast, Radical mastectomy

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To update and examine national temporal trends in contralateral prophylactic mastectomy (CPM) and determine whether survival differed for invasive breast cancer patients based on hormone receptor (HR) status and age.

Concepts: Cancer, Breast cancer, Metastasis, Pleural effusion, Breast, Mastectomy, Radical mastectomy

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The use of contralateral prophylactic mastectomies (CPMs) among patients with invasive unilateral breast cancer has increased substantially during the past decade in the United States despite the lack of evidence for survival benefit. However, whether this trend varies by state or whether it is correlated with changes in proportions of reconstructive surgery among these patients is unclear.

Concepts: Cancer, Breast cancer, United States, Chemotherapy, U.S. state, Breast, Mastectomy, Radical mastectomy

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For healthy women at high risk of developing breast cancer, a bilateral mastectomy can reduce future risk. For women who already have unilateral breast cancer, removing the contralateral healthy breast is more difficult to justify. We examined trends in the number of women who had a bilateral mastectomy in England between 2002 and 2011.

Concepts: Cancer, Breast cancer, Metastasis, Estrogen, Pleural effusion, Breast, Mastectomy, Radical mastectomy

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Guideline-concordant local therapy options for early breast cancer include lumpectomy plus whole breast irradiation (Lump+WBI), lumpectomy plus brachytherapy, mastectomy alone, mastectomy plus reconstruction, and, in older women, lumpectomy alone. We performed a comparative examination of each treatment’s complications and cost to assess their relative values.

Concepts: Cancer, Breast cancer, Metastasis, Pleural effusion, Breast, Brachytherapy, Mastectomy, Radical mastectomy

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Nipple-sparing mastectomy (NSM) has gained popularity for breast cancer treatment and prevention. There are limited data about long-term oncologic safety of this procedure.

Concepts: Cancer, Breast cancer, Metastasis, Estrogen, Pleural effusion, Breast, Mastectomy, Radical mastectomy