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Concept: October 12


To the Editor: Changing patterns of allergic sensitization to pollens have been noted around the world among schoolchildren. We report one associated with unusual winter allergic symptoms in Switzerland. Our group has gathered information on allergic symptoms and serologic findings among 15-year-olds attending school in Grabs, a village in eastern Switzerland,(1) from 1983 through 2007.(2) We measured IgE antibodies to 103 molecular allergens (using ImmunoCAP ISAC) in serum samples obtained from 54 students in 1986 and from 46 students in 2006.(3) In 2010, we retested 12 of the former students (then 39 years old) who in 1986 had had positive . . .

Concepts: Immune system, Antibody, Asthma, Immunology, Immunoglobulin E, Allergy, Ragweed, October 12


This paper addresses the levels of psychological distress experienced at age 42 years by men and women born in 1958 and 1970. Comparing these cohorts born 12 years apart, we ask whether psychological distress has increased, and, if so, whether this increase can be explained by differences in their childhood conditions.

Concepts: Childbirth, Critical thinking, Old age, Philosophy of science, Abundant number, October 12, 1901, Alternate reality game


The species Leptomyxa flabellata was described by Goodey in 1915 and re-isolated by Pussard and Pons in 1976. It seems that it was never seen (or never recognized) again since that time. The strain designated as “Leptomyxa flabellata CCAP 1546/2” was studied by Cann in 1984, however the quality of the electron microscopic images of that time was poor. Based on the cyst structure and size characters, Page in 1988 suggested that this strain is not co-specific with Goodey’s Leptomyxa flabellata, but represents a species ‘Ripidomyxa’ australiensis Chakraborty and Pussard, 1985, nowadays known as Rhizamoeba australiensis. In the present paper light- and electron-microscopic images of CCAP 1546/2 strain, which is now lost, are provided. Based on the morphological evidences it is suggested to establish it in a rank of a new species, Leptomyxa ambigua n. sp. Neither “true” L. flabellata Goodey, 1915 nor original R. australiensis Chakraborty et Pussard, 1985 are nowadays represented in the culture collections, and no original type material is available on both these species.

Concepts: Present, Time, March 4, October 12, February 5, December 12, February 28, November 19


Tyrinthia frontalis (Guérin-Méneville, 1855) is redescribed, formally recorded from Ecuador, and its type locality is questioned. Tyrinthia napoensis sp. nov. is described from Ecuador. Tyrinthia paraba Martins & Galileo, 1991, and T. turuna Martins & Galileo, 1993 are new country records for Ecuador. A key to species of Tyrinthia from Ecuador is provided.

Concepts: Biology, 1913, 1932, 1926, 1924, 1946, October 12, Longhorn beetle


On 12 October 2015, a cholera outbreak involving 65 cases and two deaths was reported in a fishing village in Hoima District, Western Uganda. Despite initial response by the local health department, the outbreak persisted. We conducted an investigation to identify the source and mode of transmission, and recommend evidence-led interventions to control and prevent cholera outbreaks in this area.

Concepts: Epidemiology, Lake, Human feces, Cholera, Source, Outbreak, October 12, Hoima


Kratom is a traditional drug from Southeast Asia that has been an emerging new substance in the United States. On August 30, 2016, the DEA announced the intention to emergency schedule kratom into Schedule I. To support this decision, the DEA cited an increase in drug seizures of kratom and an increase in calls to poison control concerning kratom. However, a short time later, on October 12, 2016, the DEA withdrew the intent to schedule kratom after public and congressional backlash. The withdrawal by the DEA was somewhat unprecedented. To better understand both decisions, the current article examines the evidence the DEA cited to support their decision to emergency schedule kratom and the degree and type of media coverage of kratom to determine if a media-driven drug panic occurred.

Concepts: Decision making, Southeast Asia, United States, Philippines, Poison, Pacific Ocean, The Current, October 12


Two new phenolic acids, ethyl pro-lithospermate (1), n-butyl pro-lithospermate (2) were isolated from Salvia yunnanensis C.H.Wright, along with nineteen known compounds (3-21). The structures of the isolated compounds were elucidated on the basis of extensive spectrometry and by comparing their physical and spectroscopic data to the literature. Among them, compounds 11, 12 and 14-16 were firstly isolated from S. yunnanensis C.H.Wright. Some of the isolated compounds were evaluated for their neuroprotection. Compounds 10-12 showed significant neuroprotective effects in PC12 cells and compounds 1, 4-7 displayed moderate neuroprotective effects.

Concepts: Spectroscopy, Cell culture, Phenols, Neuroprotection, PC12 cells, Astronomical spectroscopy, October 12


Facing a growing workload and dwindling resources, the US National Library of Medicine (NLM) created the Indexing Initiative project in 1996. This cross-library team’s mission is to explore indexing methodologies for ensuring quality and currency of NLM document collections. The NLM Medical Text Indexer (MTI) is the main product of this project and has been providing automated indexing recommendations since 2002. After all of this time, the questions arise whether MTI is still useful and relevant.

Concepts: Medicine, Marketing, Index, Library, Information science, October 12


I was disturbed to read Marc Cornock’s reply to ‘Can I read my own hospital notes?’ (opinion, 12 October).

Concepts: October 12


To describe trends in measles vaccine coverage rates and their association with socioeconomic characteristics among children from age 12 to 23 months in Vietnam from the year 2000 to 2014.

Concepts: Malaria, Vaccine, Vaccination, Smallpox, MMR vaccine, 2000, Year 2000 problem, October 12