SciCombinator

Discover the most talked about and latest scientific content & concepts.

Concept: Octafluoropropane

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To determine possible changes in thickness profiles of retinal layers in patients with rhegmatogenous retinal detachment (RRD) treated with perfluoropropane (C3F8) or silicon oil (SiO).

Concepts: Retinal detachment, Octafluoropropane

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To compare the primary anatomical outcome of pars plana vitrectomy, 360° peripheral endolaser, and 15% octafluoropropane C3F8 gas tamponade in patients with uncomplicated rhegmatogenous detachment and inferior retinal breaks, after 24-h postoperative prone positioning to similar patients with 1 week postoperative prone positioning.

Concepts: Retina, Vitrectomy, Diabetic retinopathy, Retinal detachment, Anatomy, Anatomical terms of location, Prone position, Octafluoropropane

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To evaluate the outcome of perfluoropropane (C3F8) gas injection for symptomatic vitreomacular traction (VMT) with or without Stage 2 macular hole (MH).

Concepts: Octafluoropropane

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To assess the posterior vitreous release rates following a single, office-based intravitreal injection of expansile gas in treating vitreomacular traction.

Concepts: Release, Octafluoropropane

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To evaluate the outcomes of pars plana vitrectomy and wide internal limiting membrane peeling with perfluoropropane tamponade (C3F8) for highly myopic foveoschisis-associated macular hole.

Concepts: Vitrectomy, Octafluoropropane

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Nano-/microbubbles are expected not only to function as ultrasound contrast agents but also as ultrasound-triggered enhancers in gene and drug delivery. Notably, nanobubbles have the ability to pass through tumor vasculature and achieve passive tumor targeting. Thus, nanobubbles would be an attractive tool for use as ultrasound-mediated cancer theranostics. However, the amounts of gas carried by nanobubbles are generally lower than those carried by microbubbles because nanobubbles have inherently smaller volumes. In order to reduce the injection volume and to increase echogenicity, it is important to develop nanobubbles with higher gas content. In this study, we prepared 5 kinds of fluoro-lipids and used these reagents as surfactants to generate “Bubble liposomes”, that is, liposomes that encapsulate nanobubbles such that the lipids serve as stabilizers between the fluorous gas and water phases. Bubble liposome containing 1-stearoyl-2-(18,18-difluoro)stearoyl-sn-glycero-3-phosphocholine carried 2-fold higher amounts of C3F8 compared to unmodified Bubble liposome. The modified Bubble liposome also exhibited increased echogenicity by ultrasonography. These results demonstrated that the inclusion of fluoro-lipid is a promising tool for generating nanobubbles with increased efficiency of fluorous gas carrier.

Concepts: Volume, Medical imaging, Medical ultrasonography, Ultrasound, Contrast-enhanced ultrasound, Contrast medium, Liposome, Octafluoropropane

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The typically stable Zr-based metal-organic frameworks (MOFs) UiO-66 and UiO-66-NH2 were treated with tetrafluoromethane (CF4) and hexafluoroethane (C2F6) plasmas.Through interactions between fluoride radicals from the perfluoroalkane plasma and the zirconium-oxygen bonds of the MOF, the resulting materials showed the development of mesoporosity, creating a hierarchical pore structure.It is anticipated that this strategy can be used as a post-synthetic technique for developing hierarchical networks in a variety of MOFs.

Concepts: Fluorine, Greenhouse gas, Fluorocarbon, Octafluoropropane, Perfluorocarbon, Hexafluoroethane, Tetrafluoromethane

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To determine the effects of lens status on the success rate of primary pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment using either perfluoropropane gas (C3F8) or silicone oil (SO) tamponade.

Concepts: Effect, Retina, Ophthalmology, Vitrectomy, Diabetic retinopathy, Retinal detachment, Effects unit, Octafluoropropane

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ImportanceIt is well known that altitude ascent with intravitreal gas can cause expansion of gas and intraocular pressure (IOP) elevation. According to Boyle’s law, the gas bubble will not expand unless a higher altitude than the gas insertion site has been reached. We report four cases in which intravitreal gas was injected at an altitude of 790 m (Jerusalem). All four cases developed high IOP even though they did not reach a higher altitude in their post-operative period.ObservationsA report of four patients following vitrectomy with 12% mixture of perfluoropropane and air are presented. All four patients arrived with ocular pain following the ascent by car of 765-1100 m to Jerusalem where the vitrectomy and gas insertion was conducted. Upon examination, all four patients had high IOP (30-55 mm Hg). IOP was well controlled with IOP-lowering medications. None of the patients suffered from long-term complications.Conclusions and RelevanceCaution should be taken with altitude changes in patients with intravitreal gas even if there was no ascent from the altitude in which the vitrectomy was performed.Eye advance online publication, 2 May 2014; doi:10.1038/eye.2014.83.

Concepts: Intraocular pressure, Pressure, Altitude, Ideal gas law, Octafluoropropane, Boyle's law, Combined gas law, The Ascent

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: To evaluate the use of perfluoropropane gas (C3F8) versus silicone oil (SO) for retinal detachment secondary to macular hole in patients with high myopia and posterior staphyloma.

Concepts: Physician, Carbon, Ophthalmology, Hydrocarbon, Retinal detachment, Myopia, Staphyloma, Octafluoropropane