Concept: Cohort
759
Consumption of spicy foods and total and cause specific mortality: population based cohort study
- OPEN
- BMJ (Clinical research ed.)
- Published over 5 years ago
- Discuss
To examine the associations between the regular consumption of spicy foods and total and cause specific mortality.
425
Contribution of alcohol use disorders to the burden of dementia in France 2008-13: a nationwide retrospective cohort study
- OPEN
- The Lancet. Public health
- Published almost 3 years ago
- Discuss
Dementia is a prevalent condition, affecting 5-7% of people aged 60 years and older, and a leading cause of disability in people aged 60 years and older globally. We aimed to examine the association between alcohol use disorders and dementia risk, with an emphasis on early-onset dementia (<65 years).
421
Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study
- OPEN
- BMJ (Clinical research ed.)
- Published almost 3 years ago
- Discuss
To quantify the effects of varying opioid prescribing patterns after surgery on dependence, overdose, or abuse in an opioid naive population.
339
Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies
- OPEN
- BMJ (Clinical research ed.)
- Published over 5 years ago
- Discuss
To quantify risk of overall cancer across all levels of alcohol consumption among women and men separately, with a focus on light to moderate drinking and never smokers; and assess the influence of drinking patterns on overall cancer risk.
300
Probability of an Obese Person Attaining Normal Body Weight: Cohort Study Using Electronic Health Records
- OPEN
- American journal of public health
- Published over 5 years ago
- Discuss
We examined the probability of an obese person attaining normal body weight.
293
Low-calorie sweetener use for weight control has come under increasing scrutiny as obesity, especially abdominal obesity, remain entrenched despite substantial low-calorie sweetener use. We evaluated whether chronic low-calorie sweetener use is a risk factor for abdominal obesity.
291
Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies
- OPEN
- BMJ (Clinical research ed.)
- Published almost 4 years ago
- Discuss
To examine the role of psychological distress (anxiety and depression) as a potential predictor of site specific cancer mortality.
242
To study the net economic effect of smoking on society.
217
Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study
- OPEN
- BMJ (Clinical research ed.)
- Published over 3 years ago
- Discuss
Objective To test the hypotheses that physical activity in midlife is not associated with a reduced risk of dementia and that the preclinical phase of dementia is characterised by a decline in physical activity.Design Prospective cohort study with a mean follow-up of 27 years.Setting Civil service departments in London (Whitehall II study).Participants 10 308 participants aged 35-55 years at study inception (1985-88). Exposures included time spent in mild, moderate to vigorous, and total physical activity assessed seven times between 1985 and 2013 and categorised as “recommended” if duration of moderate to vigorous physical activity was 2.5 hours/week or more.Main outcome measures A battery of cognitive tests was administered up to four times from 1997 to 2013, and incident dementia cases (n=329) were identified through linkage to hospital, mental health services, and mortality registers until 2015.Results Mixed effects models showed no association between physical activity and subsequent 15 year cognitive decline. Similarly, Cox regression showed no association between physical activity and risk of dementia over an average 27 year follow-up (hazard ratio in the “recommended” physical activity category 1.00, 95% confidence interval 0.80 to 1.24). For trajectories of hours/week of total, mild, and moderate to vigorous physical activity in people with dementia compared with those without dementia (all others), no differences were observed between 28 and 10 years before diagnosis of dementia. However, physical activity in people with dementia began to decline up to nine years before diagnosis (difference in moderate to vigorous physical activity -0.39 hours/week; P=0.05), and the difference became more pronounced (-1.03 hours/week; P=0.005) at diagnosis.Conclusion This study found no evidence of a neuroprotective effect of physical activity. Previous findings showing a lower risk of dementia in physically active people may be attributable to reverse causation-that is, due to a decline in physical activity levels in the preclinical phase of dementia.
197
Sleep patterns in children with autistic spectrum disorders: a prospective cohort study
- OPEN
- Archives of disease in childhood
- Published over 7 years ago
- Discuss
To investigate longitudinal sleep patterns in children with autistic spectrum disorders (ASDs).