Discover the most talked about and latest scientific content & concepts.

Concept: Chinese-language surnames


ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014; 370:1683-93.

Concepts: Randomized controlled trial, Shock, Trigraph, Gh, Septic shock, Sepsis, Chinese-language surnames


Huang, Shu-Chun, Kuo-Cheng Liu, Alice M.K. Wong, Shih-Chieh Chang, and Jong-Shyan Wang. Cardiovascular autonomic response to orthostatic stress under hypoxia in patients with spinal cord injury. High Alt Med Biol. 00:000-000, 2018.

Concepts: Spinal cord, Spinal cord injury, Chinese-language surnames, Wong Kar-wai


Wang, Chi, Hui Jiang, Jinyan Duan, Jingwen Chen, Qi Wang, Xiaoting Liu, and Chengbin Wang. Exploration of acute phase proteins and inflammatory cytokines in early stage diagnosis of acute mountain sickness. High Alt Med Biol. 00: 000-000, 2018.

Concepts: Chinese-language surnames


Spinster homolog 2 (SPNS2) is the membrane transporter of sphingosine-1-phosphate (S1P), and it participates in several physiologic processes by activating different S1P receptors (S1PRs). However, its functions in the nervous system remain largely unclear. We explored the important role of SPNS2 in the process of retinal morphogenesis using a spns2-deficient rat model. In the absence of the functional SPNS2 transporter, we observed progressively aggravating laminar disorganization of the epithelium at the postnatal stage of retinal development. Disrupted cell polarity, delayed cell-cycle exit of retinal progenitor cells, and insufficient migration of newborn neurons were proposed in this study as potential mechanisms accounting for this structural disorder. In addition, we analyzed the expression profiles of spns2 and s1prs, and proposed that SPNS2 regulated retinal morphogenesis by establishing the S1P level in the eye and activating S1PR3 signaling. These data indicate that SPNS2 is indispensable for normal retinal morphogenesis and provide new insights on the role of S1P in the developing retina using an established in vivo model.-Fang, C., Bian, G., Ren, P., Xiang, J., Song, J., Yu, C., Zhang, Q., Liu, L., Chen, K., Liu, F., Zhang, K., Wu, C., Sun, R., Hu, D., Ju, G., Wang, J. S1P transporter SPNS2 regulates proper postnatal retinal morphogenesis.

Concepts: Central nervous system, Nervous system, Neuron, Brain, Developmental biology, Physiology, Retina, Chinese-language surnames


‘EphB3-targeted regulation of miR-149 in the migration and invasion of human colonic carcinoma HCT116 and SW620 cells’ by Guodong Zhang, Xiaozhu Liu, Yinfeng Li, Yan Wang, Huankun Liang, Kangyan Li, Laiqing Li, Cuicui Chen, Wenqiao Sun, Shoulei Ren, Pengfei Zhu and Licheng Zhang1 . The above article from Cancer Science, first published on 3 April 2017 in Wiley Online Library ( and in Volume 108, pp. 408-418, has been retracted by the journal Editor in Chief, Yusuke Nakamura, and John Wiley & Sons Australia, Ltd. This article has been retracted as the Journal has been notified that one of the authors, Dr Guodong Zhang, misappropriated material without permission as part of this article and was subsequently found guilty of academic misconduct by The Academic Committee of Cancer Center of Guangzhou Medical University.

Concepts: John Wiley & Sons, Publishing, Editing, Retraction, Scientific misconduct, Chinese-language surnames


In a recent publication in the journal Science of the Total Environment, Die Fang et al. (2016) reported health effects of current ambient PM2.5 (particulate matters with aerodynamic diameters <2.5μm) pollution in 74 leading cities in China. It is a meaningful original study using the latest air quality surveillance data. However, we suppose their results may over-estimate the long-term exposure-response coefficients for per 10μg/m(3) increase in PM2.5 concentration. Moreover, we have concern about the linear relationship the authors assumed for long-term exposure to PM2.5 and the health outcomes. We also have concern about the sufficiency of confounder adjustment. Our suggestions are mainly based on our previous research experience and previous literature. We believe that the debate is conducive to a more accurate and more reasonable estimation of the health effects of PM2.5.

Concepts: People's Republic of China, Pollution, Particulate, Smog, Air pollution, Hundred Family Surnames, Chinese-language surnames, Cities in China


Yu et al.’s paper showed very interesting effects of high nitrogen (N) on the submerged macrophytes Vallisneria natans: active growth in the growing season enabled the macrophytes partly to overcome the ammonium stress. This result was evident in an experiment using ten pond ecosystems; however, their conclusion that shading induced by high phytoplankton biomass together with the toxicity of high ammonium contributed to the decrease of macrophytes growth was not strongly supported by the data provided in the paper. Three factors influencing how submerged macrophytes respond to high ammonium, not addressed by Yu et al.’s paper, are toxicity of ammonium/ammonia (NH4(+)/NH3), the precise extent of shading in water and species-specific characteristics of macrophytes. In conclusion, a comprehensive consideration of abiotic and biotic factors that involve in the responses of submerged macrophytes to high N is urged in future studies of the role of high N on the growth of submerged macrophytes.

Concepts: Ammonia, Ecology, Earth, Nitrogen, Biotic component, Chinese-language surnames, Abiotic component, Biotic


In the article by Xia et al., “Alterations of Rat Corticostriatal Synaptic Plasticity After Chronic Ethanol Exposure and Withdrawal,” 2006, 30:819-824, there was an error in some of the author names. Jian Xun Xia should be Jianxun Xia, Xiao Hu Zhang should be Xiaohu Zhang, Yin Bing Ge should be Yinbing Ge, and Xiao Ru Yuan should be Xiaoru Yuan. We apologize for this error. Reference Xia J, Li J, Zhou R, Zhang X, Ge Y, Yuan X (2006) Alterations of rat corticostriatal synaptic plasticity after chronic ethanol exposure and withdrawal. Alcohol Clin Exp Res 30:819-824.

Concepts: European Union, German language, Chinese-language surnames, Chinese surname, Zhou Dynasty, Shang Dynasty, Zhang Yimou, Records of the Grand Historian


This article contains the clinical characteristics of the paradoxical embolized patients and the following up results. Data included are related to the article “Paradoxical embolism: Experiences from a single center” (Zhang Hong-liang, Liu Zhi-hong, Luo Qin, Wang Yong, Zhao Zhi-hui, Xiong Chang-ming, in press) [1]. The data are obtained from the hospital records and telephone interview.

Concepts: Following, English-language films, Chinese-language surnames


Lj-RGD3 which contains three Arg-Gly-Asp (RGD) motifs was identified from the buccal glands of Lampetra japonica. In the present data article, acute toxicity of recombinant Lj-RGD3 (rLj-RGD3) was performed in Sprague Dawley (SD) rats. Tissue observation data of these SD rats treated with normal saline (NS) or rLj-RGD3 were shown. Furthermore, confocal microscope data were also shown to observe the location of FITC-labeled rLj-RGD3 in the ovarian cancer cells (HeyA8 cells). This paper contains data related to research concurrently published in “rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway” (Q. Jiang, Q. Li, J. Han, M. Gou, Y. Zheng, B. Li, R. Xiao, J. Wang, 2017) [1].

Concepts: Vitamin D, Cancer, Metastasis, Secretion, Hereditary nonpolyposis colorectal cancer, BRCA2, Chinese-language surnames, Chinese surname