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A human monoclonal antibody blocking SARS-CoV-2 infection

OPEN Nature communications | 6 May 2020

C Wang, W Li, D Drabek, NMA Okba, R van Haperen, ADME Osterhaus, FJM van Kuppeveld, BL Haagmans, F Grosveld and BJ Bosch
Abstract
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.
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