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COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids

OPEN American journal of respiratory and critical care medicine | 30 Apr 2020

MC Peters, S Sajuthi, P Deford, S Christenson, CL Rios, MT Montgomery, PG Woodruff, DT Mauger, SC Erzurum, MW Johansson, LC Denlinger, NN Jarjour, M Castro, AT Hastie, W Moore, VE Ortega, ER Bleecker, SE Wenzel, E Israel, BD Levy, MA Seibold and JV Fahy
Abstract
Coronavirus disease 2019 (COVID-19) is caused by SARS-coronavirus 2 (SARS-CoV-2). Angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) mediate viral infection of host cells. We reasoned that differences in ACE2 or TMPRSS2 gene expression in sputum cells among asthma patients may identify subgroups at risk for COVID19 morbidity.
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