Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized Single-Blinded Placebo Controlled Study
OPEN Diabetes care | 10 Jun 2019
P Behary, G Tharakan, K Alexiadou, N Johnson, NJ Wewer Albrechtsen, J Kenkre, J Cuenco, D Hope, O Anyiam, S Choudhury, H Alessimii, A Poddar, J Minnion, C Doyle, G Frost, C Le Roux, S Purkayastha, K Moorthy, W Dhillo, JJ Holst, AR Ahmed, AT Prevost, SR Bloom and TM Tan
Roux-en-Y gastric bypass (RYGB) augments postprandial secretion of glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY). Subcutaneous infusion of these hormones (“GOP”), mimicking postprandial levels, reduces energy intake. Our objective was to study the effects of GOP on glycemia and body weight when given for 4 weeks to patients with diabetes and obesity.
* Data courtesy of Altmetric.com