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P Behary, G Tharakan, K Alexiadou, N Johnson, NJ Wewer Albrechtsen, J Kenkre, J Cuenco, D Hope, O Anyiam, S Choudhury, H Alessimii, A Poddar, J Minnion, C Doyle, G Frost, C Le Roux, S Purkayastha, K Moorthy, W Dhillo, JJ Holst, AR Ahmed, AT Prevost, SR Bloom and TM Tan
Abstract
Roux-en-Y gastric bypass (RYGB) augments postprandial secretion of glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY). Subcutaneous infusion of these hormones (“GOP”), mimicking postprandial levels, reduces energy intake. Our objective was to study the effects of GOP on glycemia and body weight when given for 4 weeks to patients with diabetes and obesity.
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