Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
OPEN BMC cell biology | 19 Oct 2017
E Latorre, VC Birar, AN Sheerin, JCC Jeynes, A Hooper, HR Dawe, D Melzer, LS Cox, RGA Faragher, EL Ostler and LW Harries
Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology. However, the relationship between these two processes is opaque. Accordingly we developed a novel panel of small molecules based on resveratrol, previously suggested to alter mRNA splicing, to determine whether altered splicing factor expression had potential to influence features of replicative senescence.
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