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Surgery versus Physical Therapy for a Meniscal Tear and Osteoarthritis

OPEN The New England journal of medicine | 20 Mar 2013

JN Katz, RH Brophy, CE Chaisson, L de Chaves, BJ Cole, DL Dahm, LA Donnell-Fink, A Guermazi, AK Haas, MH Jones, BA Levy, LA Mandl, SD Martin, RG Marx, A Miniaci, MJ Matava, J Palmisano, EK Reinke, BE Richardson, BN Rome, CE Safran-Norton, DJ Skoniecki, DH Solomon, MV Smith, KP Spindler, MJ Stuart, J Wright, RW Wright and E Losina
Background Whether arthroscopic partial meniscectomy for symptomatic patients with a meniscal tear and knee osteoarthritis results in better functional outcomes than nonoperative therapy is uncertain. Methods We conducted a multicenter, randomized, controlled trial involving symptomatic patients 45 years of age or older with a meniscal tear and evidence of mild-to-moderate osteoarthritis on imaging. We randomly assigned 351 patients to surgery and postoperative physical therapy or to a standardized physical-therapy regimen (with the option to cross over to surgery at the discretion of the patient and surgeon). The patients were evaluated at 6 and 12 months. The primary outcome was the difference between the groups with respect to the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical-function score (ranging from 0 to 100, with higher scores indicating more severe symptoms) 6 months after randomization. Results In the intention-to-treat analysis, the mean improvement in the WOMAC score after 6 months was 20.9 points (95% confidence interval [CI], 17.9 to 23.9) in the surgical group and 18.5 (95% CI, 15.6 to 21.5) in the physical-therapy group (mean difference, 2.4 points; 95% CI, -1.8 to 6.5). At 6 months, 51 active participants in the study who were assigned to physical therapy alone (30%) had undergone surgery, and 9 patients assigned to surgery (6%) had not undergone surgery. The results at 12 months were similar to those at 6 months. The frequency of adverse events did not differ significantly between the groups. Conclusions In the intention-to-treat analysis, we did not find significant differences between the study groups in functional improvement 6 months after randomization; however, 30% of the patients who were assigned to physical therapy alone underwent surgery within 6 months. (Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases; METEOR number, NCT00597012 .).
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Randomization, Hospital, Physician, Surgery, Clinical trial, Arthritis, Randomness, Randomized controlled trial
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