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Risk multipliers for severe food anaphylaxis

OPEN The World Allergy Organization journal | 5 Dec 2015

PK Smith, JO Hourihane and P Lieberman
Abstract
Anaphylaxis is a severe, life threatening allergic reaction. In most fatal cases of food anaphylaxis, the fatality is not due merely to a simple, linear relationship between the allergen and exposure in a sensitized individual. Compounding factors such as the allergic disease burden-particularly the presence of asthma; comprehension of the potential severity of an event, training in the appropriate use of epinephrine, and emerging metabolic factors should be considered when assessing risk and establishing management strategies. This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.
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Concepts
Epinephrine, Allergology, Eczema, Food allergy, Mast cell, Allergen immunotherapy, Asthma, Allergy
MeSH headings
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