Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications
OPEN BMC medicine | 17 Apr 2015
M Versini, PY Jeandel, T Bashi, G Bizzaro, M Blank and Y Shoenfeld
The Hygiene Hypothesis (HH) attributes the dramatic increase in autoimmune and allergic diseases observed in recent decades in Western countries to the reduced exposure to diverse immunoregulatory infectious agents. This theory has since largely been supported by strong epidemiological and experimental evidence.
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